Brief Report

SARS-CoV-2 antibodies in adolescents living with perinatally acquired HIV

Lisa Frigati, Leonore Greybe, Shaun Barnabas, Mark Cotton, Helena Rabie
Southern African Journal of Infectious Diseases | Vol 39, No 1 | a579 | DOI: https://doi.org/10.4102/sajid.v39i1.579 | © 2024 Lisa Frigati, Leonore Greybe, Shaun Barnabas, Mark Cotton, Helena Rabie | This work is licensed under CC Attribution 4.0
Submitted: 22 September 2023 | Published: 26 March 2024

About the author(s)

Lisa Frigati, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Leonore Greybe, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Shaun Barnabas, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Mark Cotton, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Helena Rabie, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Abstract

Data on children and adolescents with HIV and coronavirus disease 2019 (COVID-19) co-infection are limited. Clinical and antibody data related to COVID-19 infection in adolescents living with perinatally acquired HIV (ALPHIV) and originally enrolled in the Children with HIV Early Antiretroviral Therapy (CHER) study were collected. We present a descriptive analysis of 53 ALPHIV who were tested for anti-SARS-CoV-2 antibodies. Just over half (53%) of the adolescents tested had positive anti-SARS-CoV-2 antibodies with only one participant describing a prior history of possible symptomatic infection.

Contribution: The study contributes to the understanding of SARS-CoV-2 infection and vaccination practices in HIV-positive adolescents.


Keywords

SARS-CoV2 antibodies; adolescents; adolescent HIV; perinatal HIV; COVID-19; vaccination.

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