Original Research

Mechanisms of antibiotic resistance in Haemophilus parainfluenzae

Regina E. Abotsi, Usha Govinden, Sabiha Y. Essack
Southern African Journal of Infectious Diseases | Vol 32, No 3 | a49 | DOI: https://doi.org/10.4102/sajid.v32i3.49 | © 2019 Regina E. Abotsi, Usha Govinden, Sabiha Y. Essack | This work is licensed under CC Attribution 4.0
Submitted: 14 May 2019 | Published: 01 October 2017

About the author(s)

Regina E. Abotsi, Antimicrobial Research Unit, School of Health Science, University of KwaZulu Natal, Durban, South Africa; School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana
Usha Govinden, Antimicrobial Research Unit, School of Health Science, University of KwaZulu Natal, Durban, South Africa
Sabiha Y. Essack, Antimicrobial Research Unit, School of Health Science, University of KwaZulu Natal, Durban, South Africa

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Abstract

Haemophilus parainfluenzae is part of the HACEK group of fastidious bacteria commonly implicated in endocarditis and bacteremia. Previously considered as a normal respiratory, oral and sometimes genitourinary commensal, it has been recognised as a pathogen that can cause life-threatening infections in both immunocompromised and healthy individuals. It has also been reported as a bacterium that can harbor transferable antibiotic resistance genes. This paper presents a literature review on the molecular mechanisms of resistance of H. parainfluenzae to commonly prescribed antibiotics and discusses areas for further research.

Keywords

β-lactams; chloramphenicol; fluoroquinolones; HACEK; Haemophilus parainfluenzae; macrolides; resistance mechanisms; tetracycline

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