Review Article

Prevalence and distribution of selected cervical human papillomavirus types in HIV infected and HIV uninfected women in South Africa, 1989–2021: A narrative review

Rixongile R. Rikhotso, Emma M. Mitchell, Daniel T. Wilson, Aubrey Doede, Nontokozo D. Matume, Pascal O. Bessong
Southern African Journal of Infectious Diseases | Vol 37, No 1 | a363 | DOI: https://doi.org/10.4102/sajid.v37i1.363 | © 2022 Rixongile R. Rikhotso, Emma M. Mitchell, Daniel T. Wilson, Aubrey Doede, Nontokozo D. Matume, Pascal O. Bessong | This work is licensed under CC Attribution 4.0
Submitted: 27 October 2021 | Published: 08 June 2022

About the author(s)

Rixongile R. Rikhotso, Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Thohoyandou, South Africa
Emma M. Mitchell, Department of Family, Community and Mental Health Systems, School of Nursing, University of Virginia, Charlottesville, United States of America
Daniel T. Wilson, Claude Moore Health Sciences Library, School of Nursing, University of Virginia, Charlottesville, United States of America
Aubrey Doede, Department of Family Medicine and Public Health, University of California San Diego, California, United States of America
Nontokozo D. Matume, HIV/AIDS & Global Health Research Programme, University of Venda, Thohoyandou, South Africa
Pascal O. Bessong, HIV/AIDS & Global Health Research Programme, University of Venda, Thohoyandou, South Africa; and, Center for Global Health Equity, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America


Share this article

Bookmark and Share

Abstract

Background: Human papillomavirus infection, a causative agent of cervical cancer, is of great concern, more so in populations with high HIV prevalence, such as South Africa.

Aim: This review aimed to examine the prevalence and distribution of selected cervical human papillomavirus (HPV) types in HIV infected and HIV uninfected women in South Africa.

Methods: PubMed and Web of Science databases were searched using key words. For data integrity, data was assessed by two authors independently. The study inclusion criteria comprised records on cervical HPV, HPV genotyping and HPV type distribution among South African women. Statistical analysis was performed using Social Science Statistics.

Results: Sixty-nine articles met the inclusion criteria for analysis. Data on cervical HPV prevalence and type distribution was available only for five of the nine provinces of South Africa. Only 4/69 studies used sequencing as an approach to identify HPV types. In a general population, HPV type 16 was the most frequent (8.80%), followed by types 35 (4.86%), 18 (4.14%), 58 and 52 with the frequency of 3.65% and 3.62%, respectively. Furthermore, the least frequent type was HPV 70 (0.74%). Both HIV infected and HIV uninfected populations had a higher prevalence of high-risk human papillomavirus (hrHPV) types 16, 18 and 35 than other HPV types; while HPV types 6, 11 and 70 were the least frequent types from these populations. Lastly, HPV 16 was the most predominant type among women with normal (2.03%) and abnormal cervical cytology (6.60%).

Conclusion: Expanding on HPV genotyping will improve the knowledge in patterns of HPV type distribution in South Africa that will further help in decision making to improve current diagnostics, and future vaccine development and assessment.

 


Keywords

HPV types; HPV prevalence; HPV; HIV; Women; South Africa

Metrics

Total abstract views: 195
Total article views: 155


Crossref Citations

No related citations found.