Email this article 
Hide
Show all
Brief Report
Fosfomycin resistance in community-acquired urinary pathogens from Western Cape, South Africa
Submitted: 29 July 2021 | Published: 19 January 2022
About the author(s)
Lesedi B. Mosime, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaMae Newton-Foot, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and, Department of Medical Microbiology, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Pieter Nel, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and, Department of Medical Microbiology, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Abstract
ral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown. This study investigated the prevalence and mechanisms of fosfomycin resistance amongst urinary pathogens in the Western Cape, South Africa. Of the 200 isolates collected during the study period (2019–2020), seven (3.5%) were fosfomycin resistant. Mutations in the glpT and uhpT transporter genes were the most common mechanism of resistance detected. These findings support the ongoing use of fosfomycin as an empiric antibiotic choice for the treatment of community-acquired UTI in this setting.
Keywords
Metrics
Total abstract views: 4827Total article views: 8360
Crossref Citations
1. Antibiotic resistance of urinary pathogens after kidney transplantation: a 10-year single-center survey in Germany
P. Weber, P. Braß, J. Jäger, L. Jacquet, S. Jansen, A. Gäckler, C. Jürgens, J. Reinold, U. Eisenberger, P.-M. Rath, A. Kribben, O. Witzke, H. Rohn
Infection vol: 53 issue: 5 first page: 1755 year: 2025
doi: 10.1007/s15010-025-02493-0
2. Antimicrobial susceptibilities of clinical bacterial isolates from urinary tract infections to fosfomycin and comparator antibiotics determined by agar dilution method and automated micro broth dilution
Jamie L. Dombach, Nancy C. Smith, Teresa Kottiri, Alicia M. Schiller, Edwin Kamau, Bonnie Chase Prokesch, Janet A. Hindler
Microbiology Spectrum vol: 13 issue: 3 year: 2025
doi: 10.1128/spectrum.01860-24
3. Epigenetic regulation and antimicrobial resistance: functional roles of DNA methylation
Rafca Daaboul, Elie El Hayek, Fares Sarraf, Charbel Yazbek, Christ Yazbek, Charbel Al Khoury, Sima Tokajian, Karin Sauer
FEMS Microbiology Reviews vol: 50 year: 2026
doi: 10.1093/femsre/fuag017
4. Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
Vittoria Mattioni Marchetti, Jaroslav Hrabak, Ibrahim Bitar
Frontiers in Cellular and Infection Microbiology vol: 13 year: 2023
doi: 10.3389/fcimb.2023.1178547
5. Effect of Colistin, Fosfomycin and Meropenem/Vaborbactam on Carbapenem-Resistant Enterobacterales in Egypt: A Cross-Sectional Study
Raghdaa Shrief, Amira H El-Ashry, Rasha Mahmoud, Rasha El-Mahdy
Infection and Drug Resistance vol: Volume 15 first page: 6203 year: 2022
doi: 10.2147/IDR.S385411
6. Bacteriological and molecular study of fosfomycin resistance in uropathogenic Escherichia coli
Ali Attaallah Ibrahim, Rana Kadhim Mohammed
Brazilian Journal of Microbiology vol: 55 issue: 2 first page: 1091 year: 2024
doi: 10.1007/s42770-024-01272-7
7. Fosfomycin susceptibility testing and resistance mechanisms in Enterobacterales in South Africa
Jessica S. Hurwitz, Mae Newton-Foot, Kristien Nel van Zyl, Pieter Nel
African Journal of Laboratory Medicine vol: 13 issue: 1 year: 2024
doi: 10.4102/AJLM.v13i1.2252