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Brief Report
Fosfomycin resistance in community-acquired urinary pathogens from Western Cape, South Africa
Submitted: 29 July 2021 | Published: 19 January 2022
About the author(s)
Lesedi B. Mosime, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaMae Newton-Foot, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and, Department of Medical Microbiology, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Pieter Nel, Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and, Department of Medical Microbiology, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Abstract
ral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown. This study investigated the prevalence and mechanisms of fosfomycin resistance amongst urinary pathogens in the Western Cape, South Africa. Of the 200 isolates collected during the study period (2019–2020), seven (3.5%) were fosfomycin resistant. Mutations in the glpT and uhpT transporter genes were the most common mechanism of resistance detected. These findings support the ongoing use of fosfomycin as an empiric antibiotic choice for the treatment of community-acquired UTI in this setting.
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Crossref Citations
1. Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
Vittoria Mattioni Marchetti, Jaroslav Hrabak, Ibrahim Bitar
Frontiers in Cellular and Infection Microbiology vol: 13 year: 2023
doi: 10.3389/fcimb.2023.1178547