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Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)

Yolandi Snyman, Andrew C. Whitelaw, Motlatji R.B. Maloba, Anneke C. Hesseling, Mae Newton-Foot
Southern African Journal of Infectious Diseases | Vol 36, No 1 | a241 | DOI: https://doi.org/10.4102/sajid.v36i1.241 | © 2021 Yolandi Snyman, Andrew C. Whitelaw, Motlatji R.B. Maloba, Anneke C. Hesseling, Mae Newton-Foot | This work is licensed under CC Attribution 4.0
Submitted: 26 August 2020 | Published: 23 February 2021

About the author(s)

Yolandi Snyman, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Andrew C. Whitelaw, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Motlatji R.B. Maloba, Department of Medical Microbiology, Faculty of Health Science, University of the Free State, Bloemfontein, South Africa; and National Health Laboratory Service, Universitas Hospital, Bloemfontein, South Africa
Anneke C. Hesseling, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Mae Newton-Foot, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; and National Health Laboratory Service, Tygerberg Hospital, Cape Town,, South Africa


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Abstract

Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.

Keywords

colistin resistance; Enterobacterales; children; healthy; communities; Cape Town; South Africa.

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