Case Report

Fluoroquinolone-resistant Salmonella typhi infection: a report of two cases in South Africa

N. Schellack, E. Bronkhorst, C. Maluleka, L. Hunt, P. Srinivas, W. Grootboom, D. Goff, P. Naicker, T. Modau, O. Babarinde
Southern African Journal of Infectious Diseases | Vol 33, No 2 | a20 | DOI: https://doi.org/10.4102/sajid.v33i2.20 | © 2019 N. Schellack, E. Bronkhorst, C. Maluleka, L. Hunt, P. Srinivas, W. Grootboom, D. Goff, P. Naicker, T. Modau, O. Babarinde | This work is licensed under CC Attribution 4.0
Submitted: 09 May 2019 | Published: 29 June 2018

About the author(s)

N. Schellack, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa
E. Bronkhorst, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria
C. Maluleka, Department of Microbiology, Sefako Makgatho Health Sciences University, Pretoria, South Africa
L. Hunt, The Ohio State University Wexner Medical Center, Columbus, United States
P. Srinivas, The Ohio State University Wexner Medical Center, Columbus, United States
W. Grootboom, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa; Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa
D. Goff, The Ohio State University Wexner Medical Center, Columbus, OH, United States
P. Naicker, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa
T. Modau, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa
O. Babarinde, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa

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Abstract

Typhoid and paratyphoid fever are acute, life-threatening febrile illnesses caused by systemic infection with the bacterium Salmonella enterica. Nineteen cases were reported in South Africa in 2016. We report on two cases of bacteraemic invasive S. typhi with fluoroquinolone resistance.

Keywords

multi-drug resistant; quinolone resistance; Salmonella typhi; S. typhi; typhoid

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