Original Research

Antimicrobial resistance surveillance in the South African private sector report for 2016

Olga Perovic, Husna Ismail, Erika Van Schalkwyk, Warren Lowman, Elizabeth Prentice, Marthinus Senekal, Chetna N. Govind
Southern African Journal of Infectious Diseases | Vol 33, No 4 | a160 | DOI: https://doi.org/10.4102/sajid.v33i4.160 | © 2019 Olga Perovic, Husna Ismail, Erika Van Schalkwyk, Warren Lowman, Elizabeth Prentice, Marthinus Senekal, Chetna N. Govind | This work is licensed under CC Attribution 4.0
Submitted: 31 May 2019 | Published: 22 October 2018

About the author(s)

Olga Perovic, Centre for Healthcare-Associated Infections (HAIs), Antimicrobial Resistance (AMR) and Mycoses, National Institute for Communicable Diseases, a division in the National Health Laboratory Service, Johannesburg; Department of Clinical Microbiology and Infectious Diseases, School of Pathology, University of Witwatersrand, Johannesburg, South Africa
Husna Ismail, Centre for Healthcare-Associated Infections (HAIs), Antimicrobial Resistance (AMR) and Mycoses, National Institute for Communicable Diseases, a division in the National Health Laboratory Service, Johannesburg, South Africa
Erika Van Schalkwyk, Centre for Healthcare-Associated Infections (HAIs), Antimicrobial Resistance (AMR) and Mycoses, National Institute for Communicable Diseases, a division in the National Health Laboratory Service, Johannesburg, South Africa
Warren Lowman, Department of Clinical Microbiology and Infectious Diseases, School of Pathology, University of Witwatersrand, Johannesburg; Department of Clinical Microbiology, Vermaak and Partners/Pathcare Pathologists, Pretoria; Wits Donald Gordon Medical Centre, Johannesburg, South Africa
Elizabeth Prentice, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
Marthinus Senekal, Pathcare Pathology Group Reference Laboratory, Goodwood, Western Cape, South Africa
Chetna N. Govind, Department of Clinical Microbiology, Lancet Laboratories, Durban; College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

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Abstract

Aim: The relevance of surveillance for antimicrobial resistance is increasingly recognised in the light of a global action plan to combat resistance. This report presents antimicrobial susceptibility testing on ESKAPE pathogens from private sector laboratories in South Africa for 2016.
Methods: Antimicrobial susceptibility testing (AST) performed on ESKAPE organisms (Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae and Escherichia coli) isolated from blood cultures at four private pathology laboratories in 2016 were analysed. Analysis and reporting of data were done via a uniform platform created by the NICD for national AST data.
Results: AST were reported on 9 029 ESKAPE organisms including 58% Enterobacteriaceae, 28% Gram-positive bacteria and 14% Gram-negative bacteria and drug-bug combination was performed following the Global Antimicrobial Surveillance System (GLASS) guidelines by the World Health Organization.
Conclusions: The most important resistance to address is a high level of ESBL in Enterobacteriaceae, which necessitates the use of carbapenems for treatment. Resistance to carbapenems is recorded in this report but not confirmation of genes by genotypic methods. During this period, no increase in vancomycin-resistant Enterococci was observed.


Keywords

antimicrobial resistance; surveillance; ESKAPE organisms

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