Original Research

Helicobacter Pylori antibiotic sensitivity pattern in dyspeptic patients in Kano, Nigeria

Ahmad K. Bello, Mohammad M. Borodo, Ahmad M. Yakasai, Abubakar D. Tukur
Southern African Journal of Infectious Diseases | Vol 34, No 1 | a125 | DOI: https://doi.org/10.4102/sajid.v34i1.125 | © 2019 Ahmad K. Bello, Mohammad M. Borodo, Ahmad M. Yakasai, Abubakar D. Tukur | This work is licensed under CC Attribution 4.0
Submitted: 29 May 2019 | Published: 17 October 2019

About the author(s)

Ahmad K. Bello, Department of Internal Medicine, Faculty of Basic Clinical Sciences, Ahmadu Bello University, Ahmadu Bello University Teaching Hospital (ABATHU), Zaria,, Nigeria
Mohammad M. Borodo, Department of Internal Medicine, Faculty of Health Sciences, Bayero University Kano, Aminu Kano Teaching Hospital, Kano, Nigeria
Ahmad M. Yakasai, Department of Infectious Diseases, Faculty of Clinical Sciences, Public Health and Diagnostic Institute, College of Medical Sciences, North-West University, Kano, Nigeria
Abubakar D. Tukur, Department of Microbiology, Faculty of Allied Health Science, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria


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Abstract

Background: Despite the high prevalence of Helicobacter pylori infection in Nigeria, in the North-West there are no studies on the antibiotic sensitivity pattern of this organism. This study aims to determine the antibiotic sensitivity pattern of this bacterium as well as bridge the gap in knowledge.

Methods: The study was cross-sectional in design. Questionnaires were administered in dyspeptic patients to obtain the relevant data. Two sets of gastric biopsy specimens were taken during upper gastrointestinal (GI) endoscopy. One set was sent to the histopathology laboratory for assessment and H. pylori identification, while the other set for culture was minced and plated on Columbia blood agar media (Oxoid Ltd, England) incubated at 37°C in an anaerobic jar containing CampyGen (Oxoid Ltd) to provide the required micro-aerobic environment. The disc diffusion method was used in determining the sensitivity pattern of isolates. Pre-treatment and post-treatment stool samples were collected from each patient for a H. pylori faecal antigen test to assess eradication rate.

Results: The sensitivity of H. pylori to amoxicillin was 9.2%, and 100% for both clarithromycin and levofloxacin. Tetracycline, metronidazole, cefuroxime, tinidazole and ciprofloxacin were 100% resitant. The prevalence of H. pylori at histology was 81.7%. Only 101 subjects had a positive H. pylori stool antigen test.

Conclusion: This study showed a high amoxicillin resistance; however, there is high sensitivity (100%) to clarithromycin and levofloxacin. We recommended that levofloxacin be adopted in preference to amoxicillin as part of triple therapy in Nigeria.


Keywords

H. pylori Antibiotic Sensitivity; Kano – Nigeria; H. pylori Culture; Histology; Clarithromycin and Levofloxacin Sensitivity.

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