Case Report

Aetiology of haemorrhagic cystitis: BK Polyomavirus and Adenovirus detection

Yoliswa Z. Chili, Menzi B. Nkosi, Nicky-Louise Byrne, Moepeng J. Maseko, Stephen N.J. Korsman, Gert U. Van Zyl
Southern African Journal of Infectious Diseases | Vol 40, No 1 | a685 | DOI: https://doi.org/10.4102/sajid.v40i1.685 | © 2025 Yoliswa Z. Chili, Menzi B. Nkosi, Nicky-Louise Byrne, Moepeng J. Maseko, Stephen N.J. Korsman, Gert U. van Zyl | This work is licensed under CC Attribution 4.0
Submitted: 10 September 2024 | Published: 11 February 2025

About the author(s)

Yoliswa Z. Chili, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; and Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Menzi B. Nkosi, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; and Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa
Nicky-Louise Byrne, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
Moepeng J. Maseko, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; and Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa
Stephen N.J. Korsman, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town; and Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Groote Schuur Hospital, Cape Town,, South Africa
Gert U. Van Zyl, Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; and Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa

Abstract

This case report details haemorrhagic cystitis in a 49-year-old female with chronic lymphocytic leukaemia (CLL), recurrent haematuria and detected BK polyomavirus (BKPyV) and adenovirus (HAdV) in urine. During chemotherapy cycles, quantitative polymerase chain reaction (PCR) assays found high HAdV load, similar to a HAdV-B2 genotype 78, a rare genotype that is closely related to HAdV-11.

Contribution: Viral interactions reveal immune system vulnerabilities.


Keywords

haemorrhagic cystitis, CLL, adenovirus, BK polyomavirus

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