Brief Report

The sting in the tail of severe falciparum malaria: Post-artesunate delayed haemolysis

Yael Benjamin, David Stead
Southern African Journal of Infectious Diseases | Vol 37, No 1 | a392 | DOI: https://doi.org/10.4102/sajid.v37i1.392 | © 2022 Yael Benjamin, David Stead | This work is licensed under CC Attribution 4.0
Submitted: 07 December 2021 | Published: 25 May 2022

About the author(s)

Yael Benjamin, Department of Internal Medicine, Frere Hospital, East London, South Africa
David Stead, Department of Internal Medicine, Frere Hospital, East London, South Africa; and, Department of Medicine, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa


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Abstract

Post-artesunate delayed haemolysis (PADH) is thought to occur because of delayed clearance of previously malarial infected erythrocytes spared by ‘pitting’ during treatment. We report a case of PADH following the treatment of Plasmodium (P.) falciparum malaria (32% parasitaemia), with a positive direct antiglobulin (DAT) test, suggesting an immune mechanism.

Keywords

malaria; zoonoses; protozoan infections; falciparum malaria; tropical diseases; haemolytic anaemia; autoimmune haemolytic anaemia

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