Original Research

CCT: a coordinate conversion tool for hepatitis B virus

Trevor Graham Bell, Mukhlid Yousif, Anna Kramvis
Southern African Journal of Infectious Diseases | Vol 34, No 1 | a153 | | © 2019 Trevor Graham Bell, Mukhlid Yousif, Anna Kramvis | This work is licensed under CC Attribution 4.0
Submitted: 31 May 2019 | Published: 07 January 2019

About the author(s)

Trevor Graham Bell, Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
Mukhlid Yousif, Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg; Current affiliation: Centre for HIV and STI: HIV Virology Section, National Institute for Communicable Diseases, National Health Laboratory Services; Department of Pathology, University of the Witwatersrand, Johannesburg, South Africa
Anna Kramvis, Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa

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Abstract

The hepatitis B virus (HBV) genome has ∼3 200 nucleotides, coding for seven proteins in four overlapping open reading frames (ORFs). Comparison of genomic coordinates between different samples and/or published literature requires manual conversion. An online tool is presented to convert nucleotide or amino acid positions between ORFs, regions and domains of the HBV genome. The user enters a position into an interactive web page, which then shows this position in all other applicable ORFs, regions or domains and plots it on a diagrammatic representation of the HBV genome. This tool assists researchers to convert coordinates, thereby facilitating comparisons between samples.

Keywords

bioinformatics; genotypes; HBV; hepatitis B virus

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